![]() Different battery sizes are treated as different ingredients, but different types of Cards, Pills, and Runes are all interchangeable. Besides every variety of coin, heart, key, and bomb, you can also scoop up Cards, Pills, Runes, and batteries. They cannot be spilled out of the bag once an item is scooped into the bag, for all intents and purposes it’s been destroyed, so think twice before scooping. The currently held pickups can be seen next to the Bag of Crafting. Swinging the bag at pickups will scoop them up into the bag. Tapping the key to use your consumable (Q by default) while the Bag of Crafting is chosen will let Tainted Cain pull his bag out, and pressing an attack key after that will swing the bag in that direction. If you pick up a regular consumable, such as a Pill or Card, you can switch between it and the bag by tapping the drop consumable key (Ctrl by default). ![]() Tainted Cain starts out with a Bag of Crafting permanently in his consumable slot. The only items exempt from this are certain “story” items such as the Polaroid, the Negative, Dad’s Note, ect. Whenever he tries to pick up an item pedestal, the item will explode into pickups such as Pennies, Keys, Bombs, and Red Hearts. If you already know how to play as Tainted Cain and are just looking for how to break the game as him, you may skip this section. You can bring this Cracked Key up to Home to unlock more tainted characters. During the Ascent, those Trinkets will get transformed into a Cracked Key, a single-use consumable version of the Red Key. The Red Key is not guaranteed to appear in subsequent playthroughs to unlock subsequent tainted characters, leave any Trinket in a boss room on your way down to Dad’s Note (this can even include the “boss” room containing Dad’s Note).If you’re playing as Cain, you’ll unlock Tainted Cain if not, you’ll have to do it again as Cain on a later playthrough. Using the Red Key on the reddish door outline in the hallway outside Mom’s bedroom will unlock a secret closet containing the tainted version of whichever character you’re playing as. Here, in Mom’s bedroom, you’ll find a chest containing the Red Key, which will also unlock the Red Key for future playthroughs. At the end you’ll reach a special floor called Home. During the Ascent, you’ll fight your way back up through modified versions of all the previous floors. The boss room contains no boss only an item, Dad’s Note. Behind the strange door is a hole to a special Mausoleum floor.Somewhere on the floor you can find a skull with an X-shaped crack in it breaking it will always reward you with a 0 – The Fool card. Note that you normally cannot leave the boss room after defeating Mom you will need to have some way to teleport out before you go in and fight Mom. This will consume the item and unlock the strange door. Bring either the Polaroid or the Negative to this door.Defeating Mother for the first time will cause a strange door to appear at the beginning of Depths II in all subsequent playthroughs of the regular path. At the end of the Antibirth path, you will fight Mother. Navigating the Antibirth levels is tricky you may want to look at a separate guide to learn how to acquire the Knife Pieces and reach the Corpse.This leads to an alternate set of levels, based on the Antibirth fan mod. Defeating Hush three times will cause a new door to appear on subsequent playthroughs whenever you defeat the boss of Basement I.Here, you will fight a powerful boss named Hush. On subsequent playthroughs, defeating Mom’s Heart (or its replacement, It Lives!) before the timer reaches 30:00 will cause a path to the Blue Womb to open up. Defeating Mom’s Heart in Womb II ten times will unlock a new area called “?”, also referred to as the Blue Womb.Defeating Mom in Depths II for the first time will end the game and unlock the Womb.Unlocking tainted characters is a long process, reserved for the very end of The Binding of Isaac’s unlock order.
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